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KMID : 0882420090770030315
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Korean Journal of Medicine
2009 Volume.77 No. 3 p.315 ~ p.320
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Integrin-linked kinase (ILK) and β-catenin expression in colon polyps
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Chae Hiun-Suk
Kim Jin-Soo
Son Hye-Suk
Roh Sang-Young
Kim Hyung-Keun
Cho Young-Seok
Lee Bo-In
Kang Jin-Hyoung
Choi Gyu-Yong
Maeng Lee-So
Chang Eun-Deok
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Abstract
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Background/Aims: Signaling pathways via integrin-linked kinase (ILK) and β-catenin are important in the initiation and progression of various malignant diseases. ILK modulates the transcription of β-catenin and is implicated in cell migration and invasiveness. Recently, premalignant colon polyps were found to express ILK and β-catenin. Therefore, we investigated the expression of ILK and β-catenin in colon polyps according to the gross morphology and pathologic type.
Methods: Based on morphology, colon polyps (62) were classified as being a pedunculated polyp (Ip, 16), sessile polyp (Is, 22), or laterally spreading tumor (LST, 24). The colon polyps were classified pathologically as tubular adenomas (TAs, 47) and hyperplastic polyps (HPs, 15). The expression levels of ILK and β-catenin in colon polyps and normal colon (6) were evaluated with immunohistochemistry.
Results: In normal colon, ILK was not expressed, and β-catenin stained in the cell membrane only. Based on the gross morphology of the colon polyps, no significant difference was seen in the expression of ILK and β-catenin (p>0.05). The expression of both ILK and β-catenin in TAs was greater than that in HPs (p<0.01): the greater the dysplasia in TAs, the more both ILK and β-catenin were expressed (p<0.05). The grade of expression of ILK was correlated with that of β-catenin in colon polyps (p<0.01).
Conclusions: The expression of ILK and β-catenin did not differ according to the morphology of colon polyps, but was expressed more in TAs than in HPs, especially in severe dysplasia.
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KEYWORD
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Colon polyps, Integrin-linked kinase, Proteins, β-catenin
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